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过去30年,有关小细胞肺癌(SCLC)的概念已发生了较大的变化。50年代SCLC虽然认为是最恶性的、外科治疗效果一般不佳,但仍与其它肺癌一样采用外科治疗。60年代英国一个临床回顾性研究指出,局限性SCLC尽管外科治疗和放疗效果都不好,但放疗稍优于外科。现在对70年代建立起来的有关SCLC的一些概念已提出质疑。放疗对原发肿瘤和脑预防照射的作用也发生疑问,外科对SCLC毫无效果的论点已不再可信,外科合用化疗已表明有效。【组织发生】多年来很多学者都认为SCLC是起源于K(Kulchitsky)细胞。它起源于神经外胚层,为所谓APUD系统的一部分,与SCLC有亲缘关系的良性支气管类癌的起源相似。APUD的概念是1966年Pearse提出的,指
Over the past 30 years, the concept of small cell lung cancer (SCLC) has undergone major changes. Although the SCLC considered it to be the most malignant and generally ineffective surgical treatment in the 1950s, it still uses surgical treatment like other lung cancers. In a retrospective study in the United Kingdom in the 1960s, localized SCLC, although surgical and radiotherapy were not effective, was slightly superior to surgery. Some questions about SCLC established in the 1970s have now been questioned. The role of radiotherapy in primary tumors and brain prophylaxis has also been questioned. The argument that surgery has no effect on SCLC is no longer credible. Surgical chemotherapy has been shown to be effective. [Organization] For many years, many scholars believed that SCLC originated from K(Kulchitsky) cells. It originated in the neuroectodermal layer and is part of the so-called APUD system. The origin of benign bronchial carcinoids that are related to SCLC is similar. The concept of APUD was proposed by Pearse in 1966.