SELDI蛋白质芯片技术,又称为表面增强激光解吸离子化飞行时间质谱(surface-enhanced laserdesorption/ionization-time of flight-mass spec-trometry,SELDI-TOF-MS),自2002年日本科学家田中耕一因发明该技术而荣获诺贝尔化学奖后,该技术发展十分迅速,目前已经广泛应用于生物技术、药学、基因学、临床诊断、生物信息等诸多领域[1]。其在临床实验诊断学中的主要工作原理是利用蛋白质芯片(proteinchip)和表面增强激光解吸离子化飞行 SELDI protein chip technology, also known as surface-enhanced laser desorption / ionization-time of flight-mass spectrometry (SELDI-TOF-MS), since 2002 Japanese scientists Tiangeng Yiyin invented The technology has won the Nobel Prize in Chemistry, the technology developed rapidly, has been widely used in biotechnology, pharmacy, genetics, clinical diagnosis, biological information and many other areas [1]. Its main working principle in clinical laboratory diagnostics is the use of protein chips (proteinchips) and surface-enhanced laser desorption ionization