In order to investigate the eutrophication degree of Yuqiao Reservoir, a hybrid method, combining principal component regression (PCR) and artificial neural network (ANN), was adopted to predict chlorophyll-a concentration of Yuqiao Reservoirs outflow. The data were obtained from two sampling sites, site 1 in the reservoir, and site 2 near the dam. Seven water variables, namely chlorophyll-a concentration of site 2 at time t and that of both sites 10 days before t, total phosphorus (TP), total nitrogen (TN), dissolved oxygen (DO), and temperature from January 2000 to September 2002, were utilized to develop models. To remove the collinearity between the variables, principal components extracted by principal component analysis were employed as predictors for models. The performance of models was assessed by the square of correlation coefficient, mean absolute error (MAE), root mean square error (RMSE) and average absolute relative error (AARE). Results show that the hybrid method has achieved more accurate prediction than PCR or ANN model. Finally, the three models were applied to predicting the chlorophyll-a concentration in 2003. The predictions of the hybrid method were found to be consistent with the observed values all year round, while the results of PCR and ANN models did not fit quite well from July to October.