目的　评估血浆交换 (PE)疗法抢救重症肌无力危象的有效性安全性。方法　 2 8例患者于确诊当日进行PE ,隔日一次 ,四次为一疗程 ,观察疗效和副作用。结果　血浆交换虽有低血压、低血钾、低血钙等副作用 ,但对症处理即可缓解 ,总有效率 89.3%。结论　PE是抢救重症肌无力危象的一种安全有效的治疗手段 ,采用必要的预防措施 ,可避免副作用的产生。 Objective To evaluate the safety of plasma exchange (PE) therapy in the rescue of crisis of myasthenia gravis. Methods 28 patients on the day of diagnosis PE, once every other day, four times as a course of treatment to observe the efficacy and side effects. Results Although the plasma exchange hypotension, hypokalemia, hypocalcemia and other side effects, but the symptomatic treatment can be alleviated, the total effective rate 89.3%. Conclusion PE is a safe and effective treatment for crisis of myasthenia gravis. With the necessary preventive measures, it can avoid the side effects.