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为探讨血清IV型胶原 (IV C)和层粘连蛋白 (LN)在系统性红斑狼疮 (SLE)患者中的临床意义 ;我们采用放射免疫法(RIA)对 34例SLE和 6 3例正常人的血清IV C和LN含量进行了测定 ,并进行治疗前后对比以及血清IV C和LN水平与其它临床指标间的直线相关关系分析。结果发现SLE组血清IV C和LN均较对照组显著升高 (P <0 0 0 0 1) ;治疗后随病情缓解较治疗前明显降低 (分别为P <0 0 0 1;0 0 0 5 )。血清LN与血清白蛋白呈显著负相关 (P <0 0 0 1) ,与 2 4h尿蛋白定量、血清免疫球蛋白M和补体C3水平之间呈明显的正相关 (P <0 0 5 ) ;血清IV C与血沉呈显著正相关 (P <0 0 5 )。上述结果提示血清IV C和LN水平在SLE患者中普遍升高 ,是评估SLE患者病情活动的重要指标
To investigate the clinical significance of serum IVC and laminin in patients with systemic lupus erythematosus (SLE), we used radioimmunoassay (RIA) in 34 SLE patients and 63 healthy controls Serum IV C and LN levels were measured and compared before and after treatment and serum IV C and LN levels and other clinical indicators of the linear correlation between the analysis. The results showed that the serum levels of IV C and LN in SLE group were significantly higher than those in control group (P <0.01 01), and the levels of IV C and LN in SLE group were significantly lower than those in control group after treatment (P 0 01 or 0 0 05 ). There was a significant negative correlation between serum LN and serum albumin (P <0 01), positive correlation with 24 h proteinuria, serum immunoglobulin M and complement C3 (P <0.05). Serum IV C was positively correlated with erythrocyte sedimentation rate (P <0.05). These results suggest that serum levels of IV C and LN are generally elevated in patients with SLE and are important indicators for assessing disease activity in patients with SLE