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目的评估2010年上海市松江区含麻疹成分疫苗(MCV)强化免疫的免疫学效果。方法采用多阶段分层随机抽样的方法,在接种1次、2次和3次及以上MCV的儿童中各抽取60人,于强化免疫前和强化免疫后1个月各采集手指末梢血0.5mL,采用ELISA定量检测麻疹病毒血清特异性IgG。结果未发现强化免疫前后的麻疹抗体阳性率存在显著性差异,而强化免疫后的麻疹保护性抗体阳性率和抗体浓度值均比强化免疫前有所上升(P<0.01)。学龄前儿童的免疫前麻疹保护性抗体阳性率和免疫前、免疫后的麻疹抗体浓度值均高于学龄期儿童(P<0.01)。MCV接种3次及以上者,其强化免疫前保护性抗体阳性率和抗体浓度值均低于接种1次或2次者(P<0.01),强化免疫后未发现显著性差异。强化免疫前完成麻疹疫苗免疫程序者,其免疫前麻疹保护性抗体阳性率和免疫前、免疫后的麻疹抗体浓度值均高于未完成者(P<0.01)。结论 MCV强化免疫能有效地提高麻疹保护性抗体阳性率和抗体浓度值。
Objective To evaluate the immunological effects of intensive immunization with measles ingredient vaccine (MCV) in Songjiang District in Shanghai in 2010. Methods A multistage stratified stratified random sampling method was used in 60 children who were inoculated with MCV once, twice, and three times and above, and 0.5 mL of finger peripheral blood was collected before intensive immunization and one month after intensive immunization , Measles virus serum-specific IgG was quantified by ELISA. The results showed that there was a significant difference in the positive rate of measles antibody before and after intensive immunization. The positive rate of measles protective antibody and the antibody concentration after the boost were higher than before immunization (P <0.01). The positive rate of measles protective antibody before immunization and the immunized measles antibody concentration of preschool children were higher than that of school-age children (P <0.01). MCV vaccinated three times or more, the positive rate of protective antibody and antibody concentration before immunization were lower than that of vaccination once or twice (P <0.01), and no significant difference was found after immunization. Before the intensive immunization, the positive rate of measles protective antibody before immunization and the immunized measles antibody before immunization were higher than those without vaccine (P <0.01). Conclusion MCV enhanced immunity can effectively improve the measles protective antibody positive rate and antibody concentration.