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目的 :观察经皮甲状腺体内乙醇注射对原发性甲亢的疗效。方法 :选择 42例确诊为Graves病(GD)的患者行经皮乙醇注射 (PEI)治疗 ,观察临床疗效、甲状腺激素水平 (TT3 、TT4 、FT3 、FT4 、TSH)及甲状腺大小的变化 ,随访半年。同时选择 47例口服抗甲状腺药物 (PATD)的患者进行对照 ,将其结果进行统计学处理及临床分析。结果 :PEI治疗 42例病人 ,其中治愈 17例 ,好转 2 4例 ,无效 1例 ,总有效率为 97 6 % ,与对照组疗效相比 ,差别无显著性 (p >0 0 5 ) ;在改善甲状腺大小方面 ,PEI组疗效明显优于对照组 ,差别有显著性 (p <0 0 1)。而且 ,PEI治疗GD未发现严重副反应。结论 :PEI治疗GD简单、实用、经济、有效 ,为GD的治疗提供了一条新的途径。
Objective: To observe the effect of transdermal thyroid ethanol injection on primary hyperthyroidism. Methods: Forty-two patients with Graves’ disease (GD) were selected for percutaneous ethanol injection (PEI). Clinical efficacy, thyroid hormone levels (TT3, TT4, FT3, FT4, TSH) and thyroid size were observed. At the same time, 47 patients with oral antithyroid drugs (PATD) were selected for comparison and the results were analyzed statistically and analyzed clinically. Results: PEI treated 42 patients, of which 17 were cured, 24 were improved, 1 was ineffective and the total effective rate was 97.6%. There was no significant difference between the two groups (p> 0.05) The improvement of thyroid size, PEI group was significantly better than the control group, the difference was significant (p <0.01). Moreover, PEI treatment of GD did not find serious side effects. Conclusion: The treatment of GD with PEI is simple, practical, economical and effective and provides a new approach for the treatment of GD.