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目的 :观察托吡酯对癫痫患者的临床疗效及耐受性。方法 :选择 5 0例癫痫患者 (儿童 30例 ,成人 2 0例 )进行托吡酯单药治疗。结果 :儿童 30例 ,发作频率减少≥ 5 0 %者 2 4例 (80 % ) ,其中完全控制者 8例 (2 6 .7% ) ;成人 2 0例 ,发作频率减少≥ 5 0 %者 14例 (70 % )、其中完全控制者 5例 (2 0 % )。就发作类型而言 ,复杂部分性发作 ,单纯部分性发作和全身性强直 阵挛发作 ,有效率分别为 5 4%、80 %及 85 %。结论 :托吡酯单药治疗对成人和儿童的多种癫痫发作类型有较好的疗效 ,且不良反应轻微 ,多可耐受
Objective: To observe the clinical efficacy and the tolerance of topiramate in patients with epilepsy. Methods: Fifty patients with epilepsy (30 children and 20 adults) were selected for topiramate monotherapy. Results: Among 30 children, 24 (80%) had seizure frequency reduction ≥ 50%, of which 8 had complete control (26.7%), 20 were adults and the frequency of seizures was reduced by 50% Cases (70%), of which 5 cases were completely controlled (20%). In terms of type of seizure, the rates of complex partial seizures, simple partial seizures and generalized tonic clonic seizures were 54%, 80% and 85%, respectively. CONCLUSIONS: Topiramate monotherapy is effective in treating multiple types of seizures in adults and children with mild and well tolerated adverse reactions