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目的研究自体骨髓单个核细胞(ABMMNCs)经冠状动脉移植对伴有异常Q波的扩张型心肌病(DCM)患者心功能的影响。方法选择2005年6月至2006年5月在哈尔滨医科大学附属第二临床医学院心内科住院的8例体表心电图伴有异常Q波的原发性DCM患者,在常规抗心衰药物治疗的同时,进行冠状动脉造影并进行ABMMNCs移植;在术前和术后3个月、6个月分别行体表心电图及超声心动图检查。结果术后3个月和6个月,8例患者左室射血分数(LVEF)、左室舒张末期内径(LVDd)、左室收缩末期内径(LVSd)虽然较术前有所改善,但差异无显著性意义(P>0.05)。患者术后心电图仍存在异常Q波,与术前无差异。结论经冠状动脉移植ABMMNCs,未证明能改善伴有Q波的DCM患者的心功能。
Objective To investigate the effect of autologous bone marrow mononuclear cells (ABMMNCs) transplanted via coronary artery on cardiac function in patients with dilated cardiomyopathy (DCM) accompanied by abnormal Q waves. Methods From June 2005 to May 2006 in Harbin Medical University Second Affiliated Hospital of Cardiology Department of Cardiology 8 cases of body surface ECG abnormal Q wave of primary DCM patients with conventional anti-heart failure drug treatment At the same time, coronary angiography and ABMMNCs transplantation were performed. Body surface electrocardiogram and echocardiography were performed before and 3 months and 6 months after operation. Results The left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVDd), and left ventricular end-systolic diameter (LVSd) were improved in 8 patients at 3 months and 6 months after operation, No significant (P> 0.05). There was still abnormal Q wave in patients with postoperative ECG, no difference with the preoperative. Conclusion Transplantation of ABMMNCs via coronary artery has not been shown to improve cardiac function in DCM patients with Q wave.