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目的:研究探讨儿童过敏性结肠炎的临床表现特征以及诊断治疗方法,为儿科过敏性结肠炎的诊疗提供理论参考依据。方法:回顾性总结分析我科在2010年1月至2012年6月期间收治的45例儿童过敏性结肠炎患儿的临床病例资料,结合患儿实验室检查、病理学检查以及治疗效果,总结过敏性结肠炎患儿的的诊断、治疗方法。结果:纯母乳喂养能够缩短过敏性结肠炎患儿住院治疗时间。45例患儿中白细胞计数高于12×109/L者16例,血液嗜酸性粒细胞比例升高者15例;贫血患儿13例。生化检查结果显示,总蛋白低下者4例,球蛋白低下者12例,患儿外周血抗体检查显示,6例患儿总IgE升高。肠镜检查发现颗粒样结节者29例,其中15例患儿出现嗜酸性粒细胞侵润≥60个/10HP,12例患者<60个/10HP;结肠镜检查未发现颗粒样结节者16例,其中14例患儿出现嗜酸性粒细胞侵润≥60个/10HP,2例患者<60个/10HP。统计学分析表明,嗜酸粒细胞浸润与镜下颗粒样结节具有相关性,差异具有统计学意义(x2=4.68,P<0.05)。结论:儿童过敏性结肠炎在临床上主要特征为便血和腹泻,患儿同时会伴有淋巴样颗粒结节,在诊断时询问患儿过敏史和病史,配合进行相关辅助检查对该病的诊断很有帮助。患儿的嗜酸粒细胞浸润与镜下颗粒样结节具有相关性。采用抗过敏奶粉以及回避饮食疗法能够有效治疗儿童过敏性结肠炎,使用白三烯受体拮抗剂治疗有效。
Objective: To investigate the clinical manifestations of children with allergic colitis and diagnosis and treatment methods for the diagnosis and treatment of pediatric allergic colitis provide a theoretical basis. Methods: The clinical data of 45 children with allergic colitis admitted to our department from January 2010 to June 2012 were retrospectively analyzed. Combined with the laboratory tests, pathological examination and treatment effect, the results were summarized Diagnosis and treatment of children with allergic colitis. RESULTS: Exclusive breastfeeding shortened hospitalization time in children with allergic colitis. 45 cases of children with leukocyte count higher than 12 × 109 / L in 16 cases, blood eosinophils increased in 15 cases; 13 cases of anemia in children. Biochemical test results showed that in 4 cases with low total protein and 12 cases with low globulin, peripheral blood antibody examination in children showed that the total IgE in 6 children was increased. Colonoscopy revealed 29 cases of granulous nodules, of which 15 cases had eosinophils infiltrated ≥ 60 / 10HP, 12 patients <60 / 10HP; no pelvic nodules were found in colonoscopy 16 Cases, of which 14 cases of children with eosinophilia infiltration ≥ 60 / 10HP, two patients <60 / 10HP. Statistical analysis showed that eosinophil infiltration and microscopic nodules were correlated, the difference was statistically significant (x2 = 4.68, P <0.05). Conclusions: The main clinical features of children with allergic colitis are blood in the stool and diarrhea. Children with lymphoid nodules are also diagnosed at the time of diagnosis and allergy history and history, with the relevant auxiliary examination of the disease diagnosis Very helpful Eosinophil infiltration in children correlated with microscopic granuliform nodules. The use of anti-allergy milk and avoidance of diet therapy can effectively treat children with allergic colitis, the use of leukotriene receptor antagonist treatment is effective.