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已发现甲功正常的Graves病人亲属中TRH异常和T_3抑制试验发生率高。在随访中可见他们的甲功发生改变的比率也增高。TSH结合抑制免疫球蛋白(TBⅡ)是Graves病发病的一可识别因素。本研究是为了确定是否在Graves病甲功正常亲属中TBⅡ增高和其他甲状腺检查异常甲状腺疾病发生率较高。 作者检查了353名甲动正常的Graves病人亲属的TBⅡ活性。其中18人TBⅡ活性增高,占5.1%。对这18人及另232人TBⅡ活性正常或阴性的亲属随访了6～30个月。随访期间检查了他们的甲状腺刺
It has been found that there is a high incidence of TRH abnormalities and T_3 inhibition in relatives of Graves with normal thyroid function. At follow-up, we can see that their rates of change of A-level function also increased. TSH binding inhibition of immunoglobulin (TB Ⅱ) is a recognizable factor in the pathogenesis of Graves disease. The purpose of this study was to determine if there is a high incidence of TB II in Graves’ disease and normal thyroid relatives and other thyroid abnormalities. The authors examined the TBII activity of 353 relatives of patients with Graves normal-to-normal Graves. Twenty-eight of them had higher TBⅡ activity, accounting for 5.1%. These 18 and 232 relatives with normal or negative TB II activity were followed up for 6 to 30 months. Their thyroid gland was examined during follow-up