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目的探讨泌乳素瘤中EMMPRIN的表达及意义。方法运用免疫组化法检测泌PRL瘤中EMMPRIN、CD34及Ki-67的蛋白表达。结果 EMMPRIN在侵袭性腺瘤中表达率(86.2%)明显高于非侵袭性腺瘤(40.6%),两者比较有显著性差异(P<0.05);在侵袭性腺瘤中EMMPRIN与MVD和Ki-67增殖指数呈正相关。结论 EMMPRIN在PRL腺瘤的表达与侵袭性密切相关,可作为判断PRL腺瘤侵袭性生长的指标;EMMPRIN可能通过诱导细胞增殖与血管生成促进腺瘤侵袭性生长。
Objective To investigate the expression and significance of EMMPRIN in prolactinomas. Methods Immunohistochemistry was used to detect the protein expression of EMMPRIN, CD34 and Ki-67 in prolactinoma. Results The positive rate of EMMPRIN in invasive adenomas was significantly higher than that in non-invasive adenomas (40.6%) (P <0.05). In invasive adenomas, EMMPRIN, MVD and Ki-67 Proliferation index was positively correlated. Conclusions The expression of EMMPRIN in PRL adenomas is closely related to invasiveness, which may be used as an index to determine the invasiveness of PRL adenomas. EMMPRIN may promote the invasiveness of adenoma by inducing cell proliferation and angiogenesis.