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目的观察外周性原始性神经外胚层肿瘤(pPNET)皮下埋植式动脉化疗的疗效。方法外周性原始神经外胚层肿瘤8例,男6例,女2例;中位年龄12.4岁。经皮下埋植式给药装置行阿霉素、顺铂联合咖啡因导向性灌注3～4次,化疗后进行手术或放射综合治疗。结果化疗后疼痛完全缓解;肿瘤病灶CR3例,PR5例,有效率100%。平均生存28.4个月,生存率37.5%。结论pPNET是一种极度恶性的小圆细胞肿瘤,皮下埋植式动脉化疗是一种有效的化疗方法,但还要辅以手术和放射治疗。
Objective To observe the effect of subcutaneous implantable arterial chemotherapy with peripheral prostatic neoplasms (pPNET). Methods Peripheral primitive neuroectodermal tumors in 8 cases, 6 males and 2 females; median age 12.4 years old. Subcutaneous implantable drug delivery device doxorubicin, cisplatin combined with caffeine-guided perfusion 3 to 4 times after chemotherapy or radiation therapy. Results The pain was completely relieved after chemotherapy. The tumor lesions were CR3 and PR5 with an effective rate of 100%. The average survival of 28.4 months, the survival rate of 37.5%. Conclusion pPNET is an extremely malignant small cell tumor. Subcutaneous implantable arterial chemotherapy is an effective chemotherapy, but it must be complemented by surgery and radiotherapy.