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目的了解多西紫杉醇加奥沙利铂及5-氟尿嘧啶的联合化疗方案治疗进展期胃癌的疗效和毒副作用。方法自2005年10月—2008年10月共选36例进展期胃癌患者入组本次临床研究,均经病理确诊。化疗方案为:多西紫杉醇75mg/m2,分成第1,8天;奥沙利铂85mg/m2,第2天;亚叶酸钙200mg/m2,静滴2h,第1～5d,5氟尿嘧啶2500mg/m2,持续泵人120h(第1～5d),每3周为1周期,共4个周期。观察化疗后肿瘤原发病灶的变化情况及化疗的不良反应。结果临床有效率55.6%,其中完全缓解(CR)5.6%(2例),部分缓解(PR)50.0%(18例),疾病稳定(SD)30.6%(11例),疾病进展(PD)13.9%(5例)。不良反应主要有骨髓抑制和消化系统反应。结论多西紫杉醇加奥沙利铂及5-氟尿嘧啶的联合化疗方案治疗进展期胃癌近期疗效显著,耐受性好。
Objective To investigate the efficacy and side effects of combination chemotherapy with docetaxel plus oxaliplatin and 5-fluorouracil in the treatment of advanced gastric cancer. Methods From October 2005 to October 2008, a total of 36 patients with advanced gastric cancer were enrolled in this study. All patients were confirmed by pathology. Chemotherapy regimen: docetaxel 75mg / m2, divided into first and eighth days; oxaliplatin 85mg / m2, the first two days; leucovorin 200mg / m2, intravenous drip 2h, the first 5d, 5 fluorouracil 2500mg / m2, continuous pump people 120h (1 ~ 5d), every 3 weeks for a period of 4 cycles. To observe the changes of the primary tumor after chemotherapy and chemotherapy adverse reactions. Results The clinical effective rate was 55.6%, of which CR was 5.6% (two cases), partial remission (PR) 50.0% (18 cases), stable disease (SD) 30.6% (11 cases) and disease progression % (5 cases). Adverse reactions are mainly myelosuppression and digestive system reactions. Conclusion Combination chemotherapy of docetaxel plus oxaliplatin and 5-fluorouracil has obvious curative effect and good tolerance in the treatment of advanced gastric cancer.