患者男,64岁,以“阵发性下肢水肿4月,皮疹40天”于2005年9月5日入院。患者于入院前4月因治疗甲癣口服伊曲康唑(斯皮仁诺胶囊),0.2g/次,2次/d,连续1周为1个疗程,停药3周后开始下一疗程。在完成第1周用药后出现双下肢自膝关节以下明显指凹性水肿,停用斯皮仁诺3天水肿消退,未予重 Male patient, 64 years old, with “paroxysmal lower extremity edema in April, rash 40 days” on September 5, 2005 admitted. Patients in April before admission for treatment of onychomycosis oral itraconazole (Sporanox capsules), 0.2g / time, 2 times / d for 1 week for a course of treatment, withdrawal 3 weeks after the start of the next course of treatment . After the completion of the first week of treatment appeared double lower limbs from the knee following the obvious concave edema, spinosy 3 days to disable edema subsided, not to be re-