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目的:研究生肌散中化瘀药丹参素对肉芽创面成纤维细胞的生物学作用。方法:体外培养肉芽组织成纤维细胞,分别加入不同浓度的丹参素,采用 CCK-8、台盼蓝计数、流式细胞仪检测丹参素对成纤维细胞生长增殖的影响。结果:丹参素对肉芽组织中的成纤维细胞有抑制作用,有统计学意义(P<0.05)。结论:生肌散中的单方丹参素对肉芽组织中的成纤维细胞有抑制作用,可防止创面的过度愈合。
OBJECTIVE: To investigate the biological effects of graduate student Yunsan Sanzhong Huatan Yao Danshen on fibroblasts in granulation wounds. METHODS: Cultured granulation tissue fibroblasts were cultured in vitro. Different concentrations of danshensu were added. CCK-8, trypan blue count, and flow cytometry were used to examine the effect of danshensu on proliferation and proliferation of fibroblasts. Results: Danshensu had inhibitory effect on fibroblasts in granulation tissue, with statistical significance (P<0.05). Conclusion: The unilateral danshensu in Shengjisan can inhibit fibroblasts in granulation tissue and prevent excessive wound healing.