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126只昆明小鼠随机分为3个组,分别给予未包裹、巯基乙酸包裹、巯基乙醇包裹纳米硫化铅。采用腹腔注射法一次性染毒0.2 ml(200 mg/kg)。于染毒后第0.5、1、6、12、24、36、48小时各时点取血,检测血铅含量。随着小鼠染毒时间的增加,血铅上升到一定峰值后逐渐降低。小鼠染毒后48 h内,3组样品中血铅浓度呈未包裹组>巯基乙酸组>巯基乙醇组,毒代动力学铅浓度-时间曲线符合一级吸收二室模型,毒代动力学参数显示,巯基乙醇组代谢最快,而未包裹组代谢最慢。提示包裹后纳米硫化铅在血中含量低,代谢速度快。
126 Kunming mice were randomly divided into three groups, respectively, were not wrapped, wrapped with thioglycolic acid, mercaptoethanol wrapped nano lead sulfide. One-time intraperitoneal injection of 0.2 ml (200 mg / kg) was used. Blood was collected at 0.5, 1, 6, 12, 24, 36, and 48 hours after exposure to the test for blood lead levels. With the increase of exposure time in mice, blood lead rose to a certain peak and then gradually decreased. Within 48 hours after exposure, the concentrations of lead in the three groups of samples were uncoated group> thioglycolic acid group> mercaptoethanol group, and the toxicokinetic lead concentration-time curve was consistent with the first-order absorption two-compartment model. The toxicokinetics The parameters showed that the mercaptoethanol group had the fastest metabolism, while the uncoated group showed the slowest metabolism. Prompt after the package nano-lead sulfide in the blood is low, fast metabolism.