“生物利用度”这一术语的含意是指经特定途径给药后到达全身循环的原药物的比率。口服给药时其生物利用度是由药物和病人两种因素来决定的,前者包括分子性质、药物稳定性和给药处方;后者诸如因腹腔疾病或肠切除所致的肠表面积减少,以及是否在就餐时服药。此处药物在肠壁、肝脏或是在肺部(少见)可能都要遭到进入全身前的代谢作用。 The term “bioavailability” means the ratio of the original drug that reaches the systemic circulation after a given route of administration. Its oral bioavailability is dictated by the drug and the patient, both of which include molecular properties, drug stability and dosing regimens; the latter, such as reduced intestinal surface area due to celiac disease or intestinal resection, and Whether to take medicine while eating. Here, the drug may be metabolized in front of the gut, in the liver, or in the lungs (rare).