为了观察内毒素休克狗血浆Ⅷ因子相关抗原(ⅧR:Ag)的动态变化,制备了兔抗狗ⅦR:Ag 血清。结果发现:内毒素休克时血浆ⅦR:Ag 明显升高,其升高程度与休克动物的预后有关,可作为判断休克预后的一个参考指标。当血小板在体外由内毒素刺激聚集时,血浆ⅧR:Ag 含量则降低。综合体内、外实验结果,对内毒素休克时血浆ⅧR:Ag 升高的机制进行了探讨。 To observe the dynamic changes of Ⅷ factor-related antigen (ⅧR: Ag) in dogs with endotoxin shock, rabbit anti-ⅦR: Ag serum was prepared. The results showed that the plasma Ⅶ R: Ag was significantly increased during endotoxic shock, and the increased level was related to the prognosis of shock animals and could be used as a reference index for judging the prognosis of shock. When platelets are stimulated by endotoxin in vitro, plasma Ⅷ R: Ag levels decrease. Based on the results of in vivo and in vitro experiments, the mechanism of elevated plasma Ⅷ R: Ag in endotoxic shock was discussed.