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Wilkins等(1951)首创用可的松抑制先天性肾上腺增殖症的雄激素分泌。Jones等(1953)和Greenblatt(1953)报道对月经紊乱或多毛,伴有轻度青春后期肾上腺皮质增殖症,及见尿内17氧(甾)类固醇(17 oxosteroid简称17-OS)者,用可的松后,产生了排卵周期,且部分患者怀孕。有鉴于此,作者用强的松治疗轻度肾上腺增殖症30例,全部受孕。此30例患者均曾经过其他治疗2～20年,其中10例曾受孕22次,但仅2例获得活婴,其余20次妊娠均流产。
Wilkins et al. (1951) pioneered the use of cortisone to inhibit androgen secretion in patients with congenital adrenal hyperplasia. Jones et al. (1953) and Greenblatt (1953) reported that for menstrual disorders or hirsutism with mild adolescent adrenal hyperplasia and for 17-oxo-steroids (17-OS) Of the loose, resulting in ovulation cycle, and some patients are pregnant. In view of this, the author treated with prednisone 30 cases of mild adrenal hyperplasia, all pregnant. All 30 patients had been treated for another 2 to 20 years, of whom 10 had 22 pregnancies, but only 2 received live births and the remaining 20 were aborted.