硬皮病是一种累及结缔组织和血管的疾病,其致病原因和发病机理迄今尚未明了。可能与免疫(特别是自体免疫)、遗传因素及胶原代谢异常有关。某些职业性有害因素,也可诱发硬皮病或硬皮病样改变。近年来,国外对其流行病学、临床、病理和实验作过观察和研究。报道了在一些毒物、粉尘的作业工人中, Scleroderma is a disease involving connective tissue and blood vessels, and its etiology and pathogenesis have not been known yet. May and immune (especially autoimmune), genetic factors and abnormal collagen metabolism. Certain occupational hazards can also cause scleroderma or scleroderma-like changes. In recent years, foreign countries have made observations and studies on their epidemiology, clinical practice, pathology and experiments. Reported in some of the toxic, dust workers,