论文部分内容阅读
目的 研究颈动脉斑块内新生血管密度与患者血清脂蛋白相关磷脂酶A2 (Lp-PLA2)水平的相关性.方法 采用酶联免疫吸附试验(ELISA)测定291例在我院进行颈动脉斑块超声造影检查的患者的血清Lp-PLA2水平,并按其超声造影结果显示斑块内新生血管分布密度分级分为三组,Ⅰ～Ⅱ级为组1(28例),Ⅲ级为组2(82例),Ⅳ级为组3(181例),比较各组间血清Lp-PLA2水平.结果 三组患者的血清Lp-PLA2水平存在显著差异,具有统计学意义(P＜0.05),三组数据两两比较,差异有统计学意义(P均＜0.05).结论 颈动脉斑块内新生血管分布密度越高,患者血清Lp-PLA2水平越高,两者存在明显的相关性,血清Lp-PLA2测定与颈动脉超声造影联合评估患者颈动脉斑块的易损性,可以更好地为临床筛查及干预治疗提供依据.“,”Objective To investigate the relationship between the density of neovascularization and the serum lipoprotein-associated pospholipase A2(Lp-PLA2) in patients with carotid plaques.Methods The serum Lp-PLA2 in 291 patients who are examinated in plaque contrast-enhanced ultrasound were detected by enzyme linked immunosor bent assay (ELISA).According to the neovascularization density grade of carotid plaque the patients were divided into three groups,grade Ⅰ-Ⅱ for group 1 (28 cases),grade Ⅲ for group 2 (82 cases),grade Ⅳ for group 3 (181 cases),then the serum Lp-PLA2 were compared between different groups.Results There were significant differences in ser um Lp-PLA2 between the three groups (P＜0.05).The difference was statistically significant between three groups (P＜0.05).Conclusions The higher the carotid plaque neovascularization density of the patients,the higher the serum Lp-PLA2.There exists obvious correlation.To evaluate the vulnerability of carotid plaque with serum Lp-PLA2 and carotid artery ultrasonography,it can provide a basis for clinical screening and intervention treatment.