1　病例介绍患者 ,女 ,46岁。 17年来反复发作性喘息样呼吸困难 ,多发生于夜间 ,早期多发生于前夜 ,3年后多发生于后夜。每次发作时均有先兆 ,先感咽喉部痒感、欲咳 ,继气喘发作 ,伴有喘鸣音、胸闷、心悸、全身冷汗、四肢冰冷、腹胀、便意和小便次数增多 ,以喘鸣症状为重而感痛 1 case description Patient, female, 46 years old. In the past 17 years, recurrent wheezing-like dyspnea occurred mostly in the night, early in the eve of the night, and more occurred in the night after 3 years. Each attack are threatened, the first sense of throat itching, cough, following asthma attacks, accompanied by wheezing, chest tightness, heart palpitations, body cold and sweat, limbs cold, bloating, convenience and urination frequency to wheezing symptoms Feel heavy and painful