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目的：探讨度洛西汀与氟西汀治疗广泛性焦虑障碍的疗效和安全性。方法将70例广泛性焦虑障碍患者按照随机数字表法分为两组，研究组口服度洛西汀治疗，对照组口服氟西汀治疗，观察6周。于治疗前后采用汉密顿焦虑量表及临床疗效总评量表‐病情严重程度分量表评定临床疗效，副反应量表评定不良反应。结果治疗1周末起两组汉密顿焦虑量表评分均较治疗前显著下降（ P＜0．05或0．01），研究组治疗1周、2周末汉密顿焦虑量表评分显著低于对照组（P＜0．01），其他时点评分两组比较差异均无显著性（P＞0．05）；治疗6周末两组临床疗效总评量表‐病情严重程度分量表评分均较治疗前有显著下降（ P＜0．01），总有效率均为82．9％。两组不良反应较轻微，研究组发生率为34．3％，对照组为37．1％，两组比较差异无显著性（χ2＝0．06， P＞0．05）。结论度洛西汀与氟西汀治疗广泛性焦虑障碍疗效显著且相当，安全性高，但度洛西汀起效更快，更有利于提高患者的治疗依从性。“,”Objective To explore the efficacy and safety of duloxetine vs .fluoxetine in the treatment of generalized anxiety disorder (GAD ) .Methods Seventy GAD patients were randomly assigned to two groups two groups ,research group took orally duloxetine and control group did fluoxetine for 6 weeks . Efficacies were assessed with the Hamilton Anxiety Scale (HAMA) and Clinical Global Impression‐severi‐ty of illness (CGI‐SI) before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results Since the end of the 1st week the HAMA scores of both groups lowered more significantly compared with pretreatment (P<0 .05 or 0 .01) ,those were significantly lower in re‐search than in control group at the ends of the 1st and 2nd week (P0 .05);at the end of the 6th week the CGI‐SI scores of both groups lowered more significantly compared with pretreatment (P0 .05) .Con‐clusion Duloxetine and fluoxetine have equivalent and evident effect and higher safety in the treatment of generalized anxiety disorder ,but the former takes effect more rapidly ,and is more beneficial to the boost of patients’ treatment compliance .