肿瘤的发生在很大程度上是因为转化的细胞不能正常凋亡所致。因此 ,研究如何促进肿瘤细胞的凋亡为肿瘤治疗提供了新的途径 ,特别是多种死亡受体及其配基的发现为肿瘤凋亡疗法的研究开辟了新的道路。本文介绍了多种死亡受体及其配基以及它们的功能调节、信号传导途径和在肿瘤治疗中的研究进展 The occurrence of tumors is largely due to the inability of the transformed cells to undergo normal apoptosis. Therefore, the study of how to promote the apoptosis of tumor cells provides a new approach for tumor treatment. In particular, the discovery of multiple death receptors and their ligands has opened up a new path for the study of tumor apoptosis therapy. This article describes the progression of multiple death receptors and their ligands as well as their function regulation, signal transduction pathways, and in the treatment of cancers.