论文部分内容阅读
对Tangier病病因的研究,发现ATP结合盒转运蛋白A1(ATP binding cassette transport protein A1,ABCA1)在胆固醇逆向转运(reverse cholesterol transport,RCT)中起重要作用。ABCA1主要通过核受体PPARs途径发挥作用。ABCA1基因变异影响其功能。
The study on the etiology of Tangier’s disease found that ATP-binding cassette transport protein A1 (ABCA1) plays an important role in the reverse cholesterol transport (RCT). ABCA1 functions primarily through the nuclear receptor PPARs pathway. ABCA1 gene mutation affects its function.