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为探讨急性链球菌感染后肾炎(APSGN)患儿血、尿白介素-8(IL-8)的变化和意义。用ELISA方法检测34例APSGN患儿急性期和恢复期及16例对照组儿童血、尿IL-8浓度。急性期患儿肾功能降低11例,肾功能正常23例。结果:APSGN患儿急性期尿IL-8水平(55.84pg/mg肌酐)较恢复期(32.55pg/mg肌酐)和对照组(11.21pg/mg肌酐)显著升高(P<0.05)。急性期肾功能降低患儿尿IL-8水平(89.97pg/mg肌酐)较肾功能正常患儿(41.00pg/mg肌酐)显著升高(P<0.05)。尿IL-8浓度与尿蛋白浓度呈显著正相关(r=0.716,P<0.01)。提示APSGN患儿尿IL-8水平与临床病情相关。
To investigate the changes of blood and urine interleukin-8 (IL-8) in children with acute streptococcal nephritis (APSGN) and its significance. The concentrations of IL-8 in blood and urine of 34 children with APSGN during acute phase and convalescent phase and 16 control group were detected by ELISA. Acute renal dysfunction in children in 11 cases, 23 cases of normal renal function. Results: The level of urinary IL-8 (55.84pg / mg creatinine) in acute stage of APSGN was significantly higher than that in convalescent phase (32.55pg / mg creatinine) and control group (11.21pg / mg creatinine) (P <0.05). Urinary IL-8 levels (89.97pg / mg creatinine) in children with acute renal failure were significantly higher than those with normal renal function (41.00pg / mg creatinine) (P <0.05). There was a significant positive correlation between urine IL-8 and urinary protein (r = 0.716, P <0.01). Tip APSGN urinary IL-8 levels in children with clinical conditions.