论文部分内容阅读
目的:通过与C反应蛋白(CRP)检测对比,探讨抗炎因子白细胞介素(IL)-10、促炎因子IL-6与急性冠状动脉综合征(ACS)的关系。方法:冠心病患者78例,其中ACS患者40例(ACS组),稳定型心绞痛(SAP组)患者38例,33例胸痛综合征(CPS组)患者作为对照。所有患者均行冠状动脉造影检查。采用ELISA法检测血浆IL-6、IL-10水平,采用免疫比浊法测定CRP值。结果:与SAP组及CPS组相比,ACS组血浆IL-10水平明显降低,IL-6、CRP水平明显升高,差异有统计学意义;SAP组IL-10水平低于CPS组,IL-6、CRP水平高于CPS组,差异无统计学意义;血浆IL-10水平与IL-6及CRP水平呈负相关,IL-6水平与CRP水平正相关。结论:血浆IL-10水平降低和IL-6、CRP值升高对患者ACS的发生有预测价值。抗炎因子和促炎因子水平的失衡是导致斑块不稳定、急性冠状动脉事件发生的重要因素。
Objective: To investigate the relationship between anti-inflammatory cytokines interleukin (IL) -10, proinflammatory cytokine IL-6 and acute coronary syndrome (ACS) by comparing with C-reactive protein (CRP) Methods: A total of 78 patients with coronary heart disease were enrolled in this study. Forty ACS patients (ACS group), 38 patients with stable angina pectoris (SAP group) and 33 patients with chest pain syndrome (CPS group) served as controls. All patients underwent coronary angiography. The plasma levels of IL-6 and IL-10 were detected by ELISA, and the CRP value was measured by immunoturbidimetry. Results: Compared with SAP group and CPS group, plasma IL-10 level was significantly decreased and IL-6 and CRP levels were significantly increased in ACS group, while IL-10 level in SAP group was lower than that in CPS group and IL- 6, CRP levels were higher than CPS group, the difference was not statistically significant; plasma IL-10 levels and IL-6 and CRP levels were negatively correlated, IL-6 levels and CRP levels were positively correlated. Conclusion: The decrease of plasma IL-10 level and the increase of IL-6 and CRP levels have predictive value for the occurrence of ACS. The imbalance of anti-inflammatory and proinflammatory cytokines is an important factor that leads to plaque instability and acute coronary events.