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目的:探讨手术去势、电切术联合间断性内分泌治疗晚期前列腺癌对患者症状改善、生活质量的影响。方法:收集2012年1月至2014年6月来我院就诊的患者220例,随机分为试验组和对照组,各110例。试验组给予手术去势、电切术联合间断性内分泌治疗,对照组仅给予间断性内分泌治疗。观察两组患者症状改善程度及生活质量差异。结果:试验组患者治疗后刺激症状得分、梗阻症状得分、IPSS评分及身体状况、社会/家庭、情感状况、生活状况和PCS评分均低于对照组,而生活质量各指标均优于对照组,分别经t检验比较,差异均有统计学意义(P<0.05)。结论:手术去势、电切术联合间断性内分泌治疗晚期前列腺癌可显著改善患者症状,提高其生活质量。
Objective: To investigate the effects of surgical castration, resection combined with intermittent endocrine therapy on the improvement of symptoms and quality of life in patients with advanced prostate cancer. Methods: A total of 220 patients who came to our hospital from January 2012 to June 2014 were randomly divided into experimental group and control group, each with 110 cases. The experimental group was given surgical castration, resection combined with intermittent endocrine therapy, the control group was given intermittent endocrine therapy. To observe the two groups of patients to improve the degree of symptoms and quality of life differences. Results: The score of symptom, symptom score, IPSS score, physical status, social / family, emotional status, living condition and PCS score of the experimental group were lower than those of the control group after treatment, but the quality of life indicators were better than the control group, After t test, the differences were statistically significant (P <0.05). Conclusion: Surgical castration, resection combined with intermittent endocrine treatment of advanced prostate cancer can significantly improve the symptoms and improve their quality of life.