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目的探讨Toll样受体4(TLR-4)和核转录因子-κB(NF-κBp50)在不同类型淋巴瘤中的表达及其意义。方法采用免疫组织化学Super Vision法检测97例恶性淋巴瘤患者组织中TLR-4和NF-κBp50表达,并分析其与临床病理特征的关系。结果 TLR-4和NF-κBp50在不同类型的淋巴瘤中皆有较高程度的表达,但各组之间差异无统计学意义(P>0.05)。TLR-4在CRP(C反应蛋白)高水平组表达高于低水平组,NF-κBp50在AnnArdor分期Ⅲ～Ⅳ期表达高于Ⅰ～Ⅱ期,差异有统计学意义(P<0.05)。结论 TLR-4和NF-κBp50在不同类型淋巴瘤中皆有较高表达,可能参与了多种类型淋巴瘤的发生、发展;TLR-4与CPR和NF-κBp50与Ann Ardor不同组间差异可能对淋巴瘤的诊断和预后有一定的意义。
Objective To investigate the expression and significance of Toll-like receptor 4 (TLR-4) and nuclear factor-κB (NF-κBp50) in different types of lymphoma. Methods The expressions of TLR-4 and NF-κBp50 in 97 cases of malignant lymphoma were detected by immunohistochemistry with Super Vision method. The relationship between TLR-4 and NF-κBp50 expression was analyzed. Results The expressions of TLR-4 and NF-κBp50 were higher in different types of lymphoma, but there was no significant difference between the two groups (P> 0.05). The expression of TLR-4 in CRP (C-reactive protein) high level group was higher than that in low level group. The expression of NF-κBp50 was higher in stage Ⅲ ~ Ⅳ of AnnArdor stage than in stage Ⅰ ~ Ⅱ, the difference was statistically significant (P <0.05). Conclusion TLR-4 and NF-κBp50 are highly expressed in different types of lymphoma and may be involved in the occurrence and development of various types of lymphoma. The differences between TLR-4, CPR, NF-κBp50 and Ann Ardor may be different Lymphoma diagnosis and prognosis of a certain significance.