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简述了一氧化氮-环磷鸟苷(NO-cGMP)信号转导途径的研究进程,包括NO的功能、合成及受体,cGMP的合成、水解及稳态水平,此信号转导通路的发现开拓了NO生理学和病理学的研究领域。从提出假设到实验验证,证实了由一氧化氮合酶(NOS)生物合成的NO通过激活鸟苷酸环化酶(GC)提高cGMP引起血管舒张,作为细胞内第二信使调控着多种生理功能。从基础研究到开发应用,假说的证实为NO-cGMP信号转导途径中基于各分子靶点开发单类药物或为药物联用提供理论依据,为临床种类众多的NO源疾病提供治疗策略,并为中药的研发带来了前景。
The progress of NO-cGMP signal transduction pathway, including the function, synthesis and receptor of NO, the synthesis, hydrolysis and steady-state of cGMP, is briefly reviewed. The signal transduction pathway Discovery has pioneered the area of NO physiology and pathology. From proposing assumptions to experimental validation, it was demonstrated that nitric oxide biosynthesized by nitric oxide synthase (NOS) enhances vasodilatation caused by cGMP by activating guanylate cyclase (GC), as a second intracellular messenger that regulates various physiological Features. From basic research to development and application, the hypothesis is confirmed as NO-cGMP signal transduction pathway based on the development of single-drug target for each drug or provide a theoretical basis for drug combination for a variety of clinical NO source disease treatment strategies and The research and development of traditional Chinese medicine has brought prospects.