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目的:观察重症COPD患者血浆蛋白和肺功能变化及重组人生长激素(rhGH)的治疗作用。方法:32名老年COPD患者接受高营养治疗并在此基础上每日皮下注射生长激素4.5单位,疗程4周。结果:受试对象体重均降低,经过治疗体重,肱三头肌皮皱(TSF),上肢臂肌围(AMC)逐渐增加,转铁蛋白,前白蛋白值均明显升高,肺功能:MMV,FEVl/FVC值较治疗前增加,之间统计学有显著差异。结论:生长激素联合营养支持治疗能提高老年慢性阻塞性肺疾病患者营养状态,提高肺功能,增加免疫力,提高社会效益和经济效益。
Objective: To observe the changes of plasma protein and pulmonary function in severe COPD patients and the therapeutic effect of recombinant human growth hormone (rhGH). Methods: Thirty-two elderly patients with COPD underwent high nutritional therapy and on this basis daily subcutaneous injections of growth hormone 4.5 units for 4 weeks. Results: The body weight of the subjects decreased. After treatment, TSF and AMC gradually increased, and the values of transferrin and prealbumin were significantly increased. The pulmonary function , FEVl / FVC values increased compared with before treatment, statistically significant differences. Conclusion: The combination of growth hormone and nutrition support therapy can improve the nutritional status of elderly patients with chronic obstructive pulmonary disease, improve lung function, increase immunity and improve social and economic benefits.