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各种诱变剂作用于精子的不同发育阶段可在接触诱变剂后不同时间出现精子畸形。精原细胞后期或初级精母细胞早期的生殖细胞对化学诱变剂较敏感。一般在接触诱变剂后第五周最易出现精子畸形或畸形率增高。 我国食品安全性毒理学评价程序、化妆品安全性评价程序和工业毒理学中均将小鼠精子畸形试验
Various mutagens acting on different developmental stages of sperm may appear sperm deformity at different times after exposure to mutagens. Early spermatogonia or primary spermatocytes germ cells are more sensitive to chemical mutagens. Generally in the fifth week after exposure to mutagens most likely to sperm deformity or deformity rate increased. China’s food safety toxicology evaluation procedures, cosmetic safety evaluation procedures and industrial toxicology in mice sperm deformity test