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随着人们生活水平的提高,肥胖人口数量急剧增加。肥胖可诱导巨噬细胞浸润到脂肪组织,产生一系列生理变化,进而引发慢性炎症,并可进一步发展成代谢综合征、心血管疾病等多种慢性疾病。黄酮类化合物广泛存在于植物中,大量研究表明,黄酮类化合物可通过抑制巨噬细胞的浸润、调节信号转导及抗氧化等途径抑制肥胖相关炎症,并降低与其相关慢性疾病的发生风险。从肥胖诱导炎症相关的发病机制出发,概述近年来黄酮类物质抑制肥胖所诱导的慢性炎症的作用机制研究进展。黄酮类化合物在调控代谢炎症及其相关疾病方面有广阔应用前景,筛选更多有效的黄酮类化合物并研究其作用机制,具有重要的理论与临床应用价值。
As people’s living standards improve, the number of obese people increases dramatically. Obesity can induce macrophages infiltration into adipose tissue, resulting in a series of physiological changes, which in turn lead to chronic inflammation, and can further develop into metabolic syndrome, cardiovascular diseases and other chronic diseases. Flavonoids are widely found in plants. A large number of studies have shown that flavonoids can inhibit obesity-related inflammation by inhibiting the infiltration of macrophages, regulating signal transduction and anti-oxidation, and reduce the risk of chronic diseases associated with them. From the pathogenesis of obesity-induced inflammation, this review summarizes the research progress of the mechanism of flavonoids inhibiting chronic inflammation induced by obesity in recent years. Flavonoids in the regulation of metabolic inflammation and related diseases have broad application prospects, screening more effective flavonoids and study its mechanism of action, has important theoretical and clinical value.