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目的： 探讨丙戊酸钠治疗迟发性运动障碍 （ Ｔ Ｄ） 的疗效。 方法： 以丙戊酸钠的低剂量和高剂量治疗 Ｔ Ｄ， 并进行对照研究。治疗前后对不自主运动量表 （ Ａ Ｉ Ｍ Ｓ） 均分比较。 结果： 两组之间治疗前后量表均分比较均无显著差异 （ Ｐ＞ ００５）。两组自身纵向治疗前后量表均分比较均有显著性差异 （ Ｐ均＜ ００１）。治疗前后量表减分率比较， 高剂量组治疗后总有效率为７５％ ， 撤药两周时的总有效率为 ８７５％ ； 低剂量组治疗后和撤药两周时的总有效率均为８７５％ 。 结论： 显示丙戊酸钠是治疗 Ｔ Ｄ 的有效药物， 以低剂量更为适宜。
Objective: To investigate the efficacy of sodium valproate in the treatment of tardive dyskinesia (T D). Methods: Td was treated with low and high doses of sodium valproate, and the control study was conducted. Before and after treatment of involuntary movement scale (A I M S) were compared. Results: There was no significant difference between the two groups in the mean scores before and after treatment (P> 005). There was significant difference between the two groups before and after longitudinal treatment (P <0.01). Before and after treatment scale reduction rate comparison, high-dose group after treatment, the total effective rate was 75%, two weeks after withdrawal of the total effective rate was 87 5%; low-dose group after treatment and withdrawal of two weeks of the total Efficiency are 87 5%. Conclusion: Sodium valproate is shown to be an effective drug for the treatment of T D, which is more appropriate at low doses.