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目的研究骨诱导活性材料引导犬前牙区拔牙窝新骨形成的能力。材料及方法将Beagle犬随机分为A、B、C 3组,每组两只。微创拔除犬下颌双侧第一侧切牙,A组填入骨诱导活性材料,B组填入羟基磷灰石生物陶瓷,C组空置(对照)。在术后4、12周制取实验样本,进行标本测量及组织学分析。结果术后4周,AB两组新骨形成量较C组多,A组与B组宽度及高度骨量吸收程度均低于对照组,且A组低于B组,差异有统计学意义;术后12周,AB两组新骨形成量明显多于C组,牙槽嵴宽度A组较B组吸收程度低,差异有统计学意义,但AB两组间高度吸收无统计学意义。结论骨诱导活性材料(OAM)具有良好的位点保存效果。
Objective To study the ability of osteoinductive materials to guide the formation of new bone in the anterior teeth of dogs. Materials and Methods Beagle dogs were randomly divided into A, B, C 3 groups, two in each group. Microinvasive removal of the first bilateral canine bilateral mandibular incisors, group A filled with osteoinductive active material, group B filled hydroxyapatite bioceramic, group C vacant (control). At 4 and 12 weeks postoperatively, experimental samples were taken for specimen measurement and histological analysis. Results After 4 weeks, the new bone formation in AB group was more than that in C group. The width and height bone absorption of group A and group B were lower than that of control group, and group A was lower than group B, the difference was statistically significant. At 12 weeks after operation, the new bone formation rate of AB group was significantly higher than that of C group. The width of alveolar ridge width group A was lower than that of B group, the difference was statistically significant, but there was no significant difference between the two groups. Conclusion Osteoinductive material (OAM) has good site preservation effect.