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化学致癌剂4,4’-亚甲基双(2-氯苯胺)[MOCA]可明显诱导雄性大鼠肝脏乙氧基异吩噁唑O-脱乙基酶[EROD]活性,该酶为细胞色素P448的标准酶。在用MOCA染毒前一小时腹腔注射维生素C(650mg/kg)或亚硒酸钠(1mg/kg),均可明显抑制EROD活性的诱导。连续经口灌胃给维生素C(150mg/kg)或亚硒酸钠(0.5mg/kg)三周,也可明显抑制MOCA对大鼠肝脏EROD活性的诱导。提示两种药物对化学致癌物在体内的代谢活化过程有干扰作用。
The chemical carcinogen 4,4’-methylene bis (2-chloroaniline) [MOCA] can obviously induce the activity of ethoxy isoxazole O-deethylase [EROD] in male rat liver, Pigment P448 standard enzyme. Induction of EROD activity was significantly inhibited by intraperitoneal injection of either Vitamin C (650 mg / kg) or sodium selenite (1 mg / kg) one hour before exposure to MOCA. Continuous oral gavage with either vitamin C (150 mg / kg) or sodium selenite (0.5 mg / kg) for three weeks also significantly inhibited MOCA induction of EROD activity in rat livers. Prompted that the two drugs interfere with the metabolic activation of chemical carcinogens in the body.