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目的:研究清热化痰活血降气方治疗慢性阻塞性肺疾病急性加重期(AECOPD)的影响。方法:将86例AECOPD患者随机分为治疗组和对照组,两组均给予西医治疗方法,治疗组加用化痰活血降气方药治疗,对两组治疗前后血清及痰中IL-8、IL-1α、TGF-β1、MCP-1的水平进行比较。结果:治疗后治疗组血清及痰中IL-8、IL-1α、TGF-β1、MCP-1的水平较治疗前明显下降,且与对照组相比,痰IL-8、IL-1α、TGF-β1、MCP-1及血清IL-8、TGF-β1、MCP-1下降有明显差异。结论:化痰活血降气方能降低AECOPD患者血清及痰中相关炎症细胞因子水平,通过改善气道和全身的炎症反应发挥治疗作用。
Objective: To study the effect of clearing away heat, reducing phlegm and blood circulation on the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: Eighty-six patients with AECOPD were randomly divided into treatment group and control group. Western medicine treatment was given to both groups. The treatment group was treated with Huatan Huoxue Jiangqi Recipe. The levels of IL-8 and IL-8 in serum and sputum -1α, TGF-β1, MCP-1 levels were compared. Results: Compared with the control group, the levels of IL-8, IL-1α, TGF-β1 and MCP-1 in the serum and sputum of the treated group were significantly decreased after treatment β1, MCP-1 and serum IL-8, TGF-β1, MCP-1 decreased significantly. Conclusion: Huatan Huoxuegaoqi can reduce serum and sputum related inflammatory cytokines in patients with AECOPD and play a therapeutic role by improving the airway and systemic inflammatory response.