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大量实验证明,蛋白转导结构域可高效携带多种类型的物质穿越细胞膜进入细胞质。因此,将蛋白转导结构域与外源抗原连接(融合)可以促进外源抗原的交叉提呈,递送外源抗原进入MHC-Ⅰ型途径进行加工提呈,从而诱导CTL应答。本文综述了蛋白转导结构域在抗原交叉提呈中的应用进展。
A large number of experiments show that protein transduction domain can efficiently carry multiple types of substances through the cell membrane into the cytoplasm. Therefore, conjugation of protein transduction domain with exogenous antigens can promote the cross-presentation of exogenous antigens and deliver exogenous antigens into MHC-I pathway for processing and presentation, thus inducing CTL responses. This review summarizes the application of protein transduction domains in the cross-presentation of antigens.