目的　探讨老年进展期胃肠道肿瘤术后腹腔化疗的临床疗效。方法　对 1992年 1月至 1997年 10月 178例 60岁以上行根治性手术后的老年进展期胃肠道肿瘤术后行腹腔化疗的病例进行回顾性分析。并将之与同期行常规静脉化疗的 12 4例进行分析比较。结果　 178例腹腔化疗病人中 165例完成 6个疗程的全部化疗 ,完成率为 92 .7%。 12 4例静脉化疗病人中只有 85例完成全部的 6个疗程的化疗 ,完成率为 68.5%。 2年生存率(60 6% )、3年生存率 (55 8% )、5年生存率 (51 5% )高于静脉化疗组 (45 9%、41 1%、3 7 6% ) (P <0 0 5)。结论　老年进展期胃肠道肿瘤术后行腹腔化疗 ,药物的毒副反应小 ,病人耐受性好 ,化疗后腹腔转移率 ,肝转移率和血清肿瘤标记物水平明显低于静脉化疗组 ,术后 5年生存率明显提高 Objective To investigate the clinical effect of postoperative intraperitoneal chemotherapy in advanced gastrointestinal cancer. Methods A retrospective analysis was performed on 178 patients aged 60 years and above who underwent radical celiotomy after advanced surgery for gastrointestinal tract cancer from January 1992 to October 1997. And compared with 12 4 cases of routine venous chemotherapy in the same period. Results Among the 178 patients with intraperitoneal chemotherapy, 165 completed 6 cycles of chemotherapy, with a completion rate of 92.7%. Only 85 out of 124 IV chemotherapy patients completed all 6 courses of chemotherapy, with a completion rate of 68.5%. The 2-year survival rate (60 6%), 3-year survival rate (55 8%) and 5-year survival rate (51 5%) were higher than those in the intravenous chemotherapy group (45 9%, 41 1%, 37 6% <0 0 5). Conclusions Intraperitoneal chemotherapy after advanced gastrointestinal neoplasms was performed. The drug had little side effects and good patient tolerance. The peritoneal metastasis rate, hepatic metastasis rate and serum tumor marker level after chemotherapy were significantly lower than those of intravenous chemotherapy group After 5 years survival rate improved significantly