5－氟尿嘧啶（5－FU）是最常用的消化道肿瘤的化疗药物。大部份内科医师熟悉它的胃肠道反应和骨髓毒性。随着5－FU使用的增加，国外对其心服毒性屡见报道。据现有资料统计显示病人的心脏毒性发病率为1～18％，有必要引起临床医师的重视。本文就这一方面作一综述。15－Fu的药理 5-Fluorouracil (5-FU) is the most commonly used chemotherapeutic drug for gastrointestinal tumors. Most physicians are familiar with its gastrointestinal and bone marrow toxicity. As the use of 5-FU increases, its ecotoxicological effects are frequently reported abroad. According to the existing statistics show that the incidence of cardiac toxicity in patients is 1 to 18%, it is necessary to arouse the attention of clinicians. This article gives a summary of this aspect. Pharmacology of 15-Fu