目的 探讨颈椎零切迹自锁融合器在颈椎前路钛板内固定术中的应用价值.方法 选取2014年1月—2016年10月喀什地区第一人民医院脊柱外科收治的80例颈椎退行性病变患者,按照内固定方式不同分为对照组及观察组,每组40例.观察两组手术相关指标、术后神经及颈椎功能恢复情况、颈椎前凸角、颈椎间隙高度随访情况、植骨融合情况及术后并发症发生率.结果 两组术中出血量、术后引流量、住院时间比较差异无统计学意义(P>0.05),观察组手术时间较对照组显著缩短(P0.05);两组术后JOA评分较术前升高,NDI评分较术前降低,颈椎前凸角、颈椎间隙高度较术前增大,且术后观察组的各项指标高于对照组(P<0.05);术后观察组植骨总融合率高于对照组,并发症发生率低于对照组(P 0. 05). Operative time in observation group was significantly shorter than that in control group (P 0. 05). After operation, JOA scores were significantly increased, while NDI scores were significantly decreased, and values of cervical lordosis an-gle and intervertebral space height were significantly increased in two groups, and postoperative indexes values in observa-tion group were higher than those in control group (P < 0. 05). In observation group, the total fusion rate of bone graft was significantly high, while incidence rate of postoperative complications was lower than those in control group (P <0. 05). Conclusion Cervical non-notch self-locking fusion cage in application of cervical anterior internal fixation with titanium plate may effectively shorten operative time, promote recovery of nerve and cervical functions, significantly im-prove cervical physiological curvature and maintain intervertebral space height with high total fusion rate of bone graft and few complications.