[目的]了解2012年济南市手足口病家庭聚集性疫情流行特征。[方法]对2012年济南市报告的61起手足口病家庭聚集性疫情相关调查资料进行分析。[结果]2012年济南市共报告手足口病家庭聚集性疫情61起,发病122例。122例中,5岁以下儿童94例(占77.05%)。61起分布在10个县(市)区,其中农村地区28起;5～7月33起;兄弟聚集30起,双胞胎聚集26起,父子聚集5起;疫情持续时间中位数为2.05d。实验室检测26起,CoxA16和EV71单一阳性的分别为13和4起,同时阳性的2起,EV71病毒和其他肠道病毒同时阳性的1起,其他肠道病毒阳性的3起。[结论]农村和城乡结合部是济南市手足口病家庭聚集性疫情的重点区域。 [Objective] To understand the epidemic characteristics of HFMD in Jinan in 2012. [Method] The data of 61 survey cases of hand-foot-mouth disease family aggregation epidemic reported in Jinan in 2012 were analyzed. [Results] Jinan City in 2012 reported a total of 61 cases of hand-foot-mouth disease family aggregation, incidence of 122 cases. In 122 cases, 94 children under 5 years old (77.05%). 61 were distributed in 10 counties (cities) districts, of which 28 in rural areas; May to July 33; brothers gathered 30, 26 twins gathered, father and son gathered 5; the median duration of the epidemic was 2.05d. Of 26 tested in the laboratory, 13 and 4 were positive for CoxA16 and EV71, respectively, with 2 positives, 1 positive for EV71 and other enteroviruses, and 3 for other enterovirus positives. [Conclusion] The combination of rural area and urban area is the key area of ​​family aggregation epidemic in Jinan City.