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目的提高对药物性肝损害的认识和诊断治疗的准确性。方法对本院48例药物性肝损害(DILI)患者的临床资料进行回顾性分析。结果在药物性肝损害患者中,抗菌素19例(39.6%),居首位,其次为解热镇痛类11例(22.9%)和中药10例(20.8%)。临床主要表现为巩膜黄染(55.6%)、乏力(47.2%)、食欲不振(44.4%);临床上急性肝炎最常见,占90%。结论药物性肝损害随着药物的不断开发应用而逐步增加,应重视药物的肝毒性,预防药物性肝炎发生。
Objective To improve the understanding of drug-induced liver damage and the accuracy of diagnosis and treatment. Methods The clinical data of 48 patients with drug-induced liver damage (DILI) in our hospital were retrospectively analyzed. Results Among the patients with drug-induced liver injury, 19 cases (39.6%) were antibiotics, followed by anti-pyretic analgesia in 11 cases (22.9%) and traditional Chinese medicine in 10 cases (20.8%). Clinical manifestations of scleral yellow dye (55.6%), fatigue (47.2%), loss of appetite (44.4%); the most common clinical acute hepatitis, 90%. Conclusion Drug-induced liver damage gradually increases with the continuous development and application of drugs. Hepatotoxicity of drugs should be emphasized to prevent the development of drug-induced hepatitis.