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分析58例鼻咽癌患者和54例IgA/VCA抗体阳性者的染色体脆性部位,并与正常人对照,发现鼻咽癌患者染色体畸变率明显高于其他两组。从非随机的脆性部位断裂点分析中,提出脆性部位5P~(13)、5P~(14)和8P~(24)及其相应部位癌基因激活可能与鼻咽癌发生有关;非脆性部位断裂点1P~(11)、1 cen、2P~(23)和5P~(34)及相应部位癌基因激活也可能对肿瘤的发生起作用。而出现频率较高的脆性部位3P~(14)3P~(14)则与肿瘤的发生没有特异相关。
The chromosomal fragile sites of 58 NPC patients and 54 IgA/VCA-positive patients were analyzed and compared with normal controls. The chromosome aberration rate of NPC patients was significantly higher than that of the other two groups. From the analysis of non-random brittle fracture points, it is suggested that oncogene activation of 5P~(13), 5P~(14) and 8P~(24) and their corresponding sites in fragile sites may be related to nasopharyngeal carcinogenesis; non-brittle site breaks Activation of oncogenes at sites 1P-11, 1cen, 2P-23, and 5P34 and their corresponding sites may also contribute to tumorigenesis. However, 3P14P3P14 with a high frequency of occurrence was not specifically related to tumorigenesis.