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目的研究腹腔镜手术后应用米非司酮治疗子宫内膜异位症的效果及不良效果。方法选择2008年10月～2010年9月进行手术后保守治疗子宫内膜异位症的患者81例,其中45例采用米非司酮治疗、36例采用孕三烯酮治疗。治疗后进行随访1年,评价两种药物停药后治疗效果并对其不良反应进行比较。结果两组患者停药后3个月、6个月1年与治疗前比较,症状和体征均好转(P<0.05)。两组缓解率差异无统计学意义(P>0.05)米非司酮组在体重增加、痤疮、关节疼和转氨酶有明显的低于孕三烯酮治疗组(P<0.05)。米非司酮组在停药后排卵时间和月经恢复时间都明显低于孕三烯酮组。结论采用米非司酮治疗手术后子宫异位症效果良好且不良反应小,值得推广使用。
Objective To study the efficacy and adverse effects of mifepristone in the treatment of endometriosis after laparoscopic surgery. Methods Eighty-one patients with conservative endometriosis after surgery were selected from October 2008 to September 2010, of which 45 were treated with mifepristone and 36 with gestrinone. After treatment for 1 year follow-up, evaluation of two drugs after stopping the treatment effect and its adverse reactions were compared. Results After 3 months, 6 months and 1 year after stopping, the symptoms and signs of two groups were improved (P <0.05). There was no significant difference in remission rate between the two groups (P> 0.05). The body weight, acne, joint pain and aminotransferase in the mifepristone group were significantly lower than those in the gestrinone treatment group (P <0.05). Mifepristone group after stopping the ovulation time and menstruation recovery time were significantly lower than gestrinone group. Conclusion Mifepristone is effective in treating post-operative uterine ectopic disease and its adverse reaction is small, which is worth promoting.