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目的：研究糖尿病前期（PDM）发生高尿酸血症时与相关因素之间的关系。方法收集糖尿病前期患者112例，根据血尿酸水平分为正常尿酸组（NUA）57例和高尿酸（HUA）组55例，比较两组间年龄、血压、BMI、腰围身高比（WSR）、TC、TG、HDL-C、LDL-C、HOMA-IR、ISI等指标的差异。结果①HUA组的BMI、WHR、TG、HOMA-IR明显高于NUA组（<0.01)，HDL-C、ISI明显低于NUA组（<0.01)；②PDM患者中，TG、BMI与UA呈正相关，ISI与UA呈负相关，男性较女性尿酸更高。结论 PDM患者的血尿酸水平受到性别、TG、BMI等多种因素的影响，HUA与胰岛素抵抗、高脂血症、肥胖等因素密切相关。“,”Objective To study on relationship of PDM and hyperuricemia and discuss the related factors.Methods 112 pre-diabetes mellitus patients were selected and divided into NUA group (57cases) and HUA group (55cases), to compare the differences between uric acid and biochemical indicators. Results There were significant differences in BMI,WHR, TG, HOMA-IR in higher lever and HDL-C,ISI in lower lever in test group than those in control group.The uric aic level were positive relation with TG,BMI and negtive relation with ISI.Men had higher uric acid than women. Conclusion The uric acid level of PDM might be related with muhiple factors such as gender,TG,BMI. HUA should closely related with HOMA-IR, hyperlipidemia and obesity.