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在许多人类和实验性肾小球肾炎中,发现肾小球内纤维蛋白沉积是显著的,并且在某些情况下,抗凝作用对于肾脏损害的严重性和进展,显然发挥了主要作用。因为肾病是导致系统性红斑狼疮(SLE)死亡的主要原因,及目前关于凝结在SLE肾炎患者中作用的报道的缺乏和混乱,作者用碘~(125)标记纤维蛋白原的方法对一些SLE患者进行纤维蛋白原活性的研究。研究结果:在16例SLE患者的18次研究中,纤维蛋白原半衰期在该病之活动期明显缩短,其值为60.5±12小时,对照组的正常范围为90.1±11小时,t测定有统计学意义;7例临床上有肾脏疾病证据者同11例无肾脏累及者相比,发现具有肾脏病
In many human and experimental glomerulonephritis, glomerular fibrin deposition is found to be significant, and in some cases anticoagulation has apparently played a major role in the severity and progression of kidney damage. Because nephropathy is the leading cause of systemic lupus erythematosus (SLE) death and the current lack of reported clotting in the role of coagulation in patients with SLE nephritis, the authors used iodine 125 125 labeled fibrinogen for some SLE patients Fibrinogen activity was studied. RESULTS: In 18 studies of 16 patients with SLE, the half-life of fibrinogen was significantly shorter in the active phase of the disease, with a value of 60.5 ± 12 hours and a normal range of 90.1 ± 11 hours in the control group, with statistics for t Learning significance; 7 cases of clinical evidence of kidney disease with 11 cases of renal involvement compared to found with kidney disease