帕金森病(parkinson’s disease,PD)是一种常见于中老年人的神经系统退行性疾病,其典型的临床特征是肌僵直、动作迟缓、姿势步态异常和静止性震颤。特发性帕金森病的发病率约为85%,远高于发生率为15%的常染色体遗传性帕金森病[1]。老年帕金森病的患病率随年龄增长而不断增加,60岁年龄组为1%,80岁年龄组为3%[2]。目前,帕金森病的病因和发病机制尚未完全阐明,可能与年龄、 Parkinson’s disease (PD) is a neurodegenerative disease common in the elderly. Its typical clinical features are muscle rigidity, slow movement, abnormal posture gait and rest tremor. The incidence of idiopathic Parkinson’s disease is about 85%, far higher than the incidence of autosomal dominant Parkinson’s disease [15] [1]. The prevalence of senile Parkinson’s disease increases with age, with 1% in the 60-year-old group and 3% in the 80-year-old group [2]. At present, the etiology and pathogenesis of Parkinson’s disease have not yet been fully elucidated, may be related to age,