论文部分内容阅读
目的探讨婴幼儿毛细支气管炎治疗中干扰素两种不同给药方式对临床疗效及安全性的影响。方法选取2014年3月—2017年3月收治的毛细支气管炎患儿108例作为研究对象,采用随机数字法将其分为雾化组和注射组各54例,注射组给予肌肉注射治疗,雾化组给予干扰素雾化吸入给药方式治疗,观察并记录两组患儿各项体征及临床症状缓解消失时间,记录两组患儿的临床疗效情况,计数资料比较采用t检验,计量资料比较采用c2检验,P<0.05为差异有统计学意义。结果雾化组患儿在退烧时间、咳喘缓解时间、呼吸憋闷消失时间、肺部哮鸣音消失时间上均优于注射组,差异有统计学意义(P<0.05)。两组患儿临床疗效对比,雾化组总有效率96%,注射组总有效率94%,差异无统计学意义(P>0.05)。结论婴幼儿毛细支气管炎治疗中,两种给药方法临床疗效显著,干扰素雾化吸入给药方式起效更快。
Objective To investigate the effects of two different modes of administration of interferon on the clinical efficacy and safety of infantile bronchiolitis. Methods A total of 108 children with bronchiolitis who were admitted to our hospital from March 2014 to March 2017 were selected as study subjects. The patients were divided into atomization group and injection group (n = 54) by random number method. The injection group was treated with intramuscular injection and fog The patients in group A and group A were treated with inhalation of interferon nebulized. The signs and the disappearance time of clinical symptoms in both groups were observed and recorded. The clinical efficacy of the two groups were recorded. The t test was used to compare the count data and the measurement data were compared Using c2 test, P <0.05 for the difference was statistically significant. Results In the atomization group, the children were better than the injection group in the time of fever, relief of cough and asthma, disappearance of breath suppression, and disappearance of lung wheeze. The difference was statistically significant (P <0.05). The two groups of children with clinical efficacy comparison, the total efficiency of the atomization group was 96%, 94% of the total effective rate of injection group, the difference was not statistically significant (P> 0.05). Conclusions In the treatment of infantile bronchiolitis, the clinical efficacy of the two administration methods is remarkable, and the interferon injection by aerosol inhalation has a faster onset of action.